Karl Gruber, list of publications (3/2013)

Karl Gruber, list of publications (3/2013)

Karl Gruber, list of publications (3/2013)
Articles
1.
Ruetz, M., C. Gherasim, K. Gruber, S. N. Fedosov, R. Banerjee, and B. Kräutler. 2013.
Access to organometallic aryl-cobaltcorrins through radical synthesis: 4-ethylphenylcobalamin, a potential ‘antivitamin-B12’. Angew. Chem. Int. Ed. 52:2606-2610.
2.
Wuensch, C., J. Gross, G. Steinkellner, K. Gruber, S. M. Glueck, and K. Faber. 2013.
Asymmetric enzymatic hydration of hydroxystyrene derivatives. Angew. Chem. Int. Ed.
52:2293-2297.
3.
Gössweiner-Mohr, N., L. Grumet, A. Karsten, T. Pavkov-Keller, C. C. Gruber, K. Gruber,
R. Birner-Grünberger, A. Kropec-Huebner, J. Huebner, E. Grohmann, and W. Keller.
2013. The 2.5Å structure of the Enterococcus conjugation protein TraM resembles VirB8 Type
IV secretion proteins J. Biol. Chem. 288:2018-2028.
4.
Bezerra, M. J. B., N. V. F. C. Rodrigues, A. d. F. Pires, G. A. Bezerra, K. L. d. L. Alencar,
P. M. G. Soares, K. S. d. Nascimento, C. S. Nagano, J. L. Martins, K. Gruber, P.
Delatorre, B. A. M. d. Rocha, A. M. S. Assreuy, and B. S. Cavada. 2013. Crystal structure
of Dioclea violacea lectin and a comparative study of vasorelaxant properties with Dioclea
rostrata lectin. Int. J. Biochem. Cell B. 45:807-815.
5.
Bezerra, G. A., E. Dobrovetsky, R. Viertlmayr, A. Dong, A. Binter, M. Abramić, P.
Macheroux, S. Dhe-Paganon, and K. Gruber. 2012. Entropy driven binding of opioid
peptides induces a large domain motion in human dipeptidyl peptidase III. Proc. Natl. Acad.
Sci. USA 109:6525-6530.
6.
Lang, B. S., A. C. F. Gorren, G. Oberdorfer, M. V. Wenzl, C. M. Furdui, L. B. Poole, B.
Mayer, and K. Gruber. 2012. Vascular bioactivation of nitroglycerin by aldehyde
dehydrogenase-2: reaction intermediates revealed by crystallography and mass spectrometry.
J. Biol. Chem. 287:38124-38134.
7.
Oberdorfer, G., A. Binter, C. Ginj, P. Macheroux, and K. Gruber. 2012. Structural and
functional characterization of NikO, an enolpyruvyl transferase essential in nikkomycin
biosynthesis. J. Biol. Chem. 287:31427-31436.
8.
Wallner, S., A. Winkler, S. Riedl, C. Dully, S. Horvath, K. Gruber, and P. Macheroux.
2012. Catalytic and structural role of a conserved active site histidine in berberine bridge
enzyme. Biochemistry 51:6139-6147.
9.
Andexer, J. N., N. Staunig, T. Eggert, C. Kratky, M. Pohl, and K. Gruber. 2012.
Hydroxynitrile lyases with α/β-hydrolase fold: two enzymes with almost identical 3D-structures
but opposite enantioselectivities and different reaction mechanisms. ChemBioChem 13:19321939.
10.
Bezerra, G. A., E. Dobrovetsky, A. Dong, A. Seitova, L. Crombett, L. M. Shewchuk, A. M.
Hassell, S. M. Sweitzer, T. D. Sweitzer, P. J. McDevitt, K. O. Johanson, K. M. KenedyWilson, D. Cossar, A. Bochkarev, K. Gruber, and S. Dhe-Paganon. 2012. Structures of
human dipeptidyl peptidase 7 reveal the molecular basis of specific inhibition and the
architectural diversity of proline-specific peptidases. PLoS One 7:e43019.
11.
Resch, V., H. Lechner, J. H. Schrittwieser, S. Wallner, K. Gruber, P. Macheroux, and W.
Kroutil. 2012. Inverting the regioselectivity of the berberine bridge enzyme by employing
customized fluorine-containing substrates. Chem. Eur. J. 18:13173-13179.
12.
Damm, M., C. Nusshold, D. Cantillo, G. N. Rechberger, K. Gruber, W. Sattler, and C. O.
Kappe. 2012. Can electromagnetic fields influence the structure and enzymatic digest of
proteins? A critical evaluation of microwave-assisted proteomics protocols. J. Proteomics
75:5533-5543.
13.
Oberdorfer, G., K. Gruber, K. Faber, and M. Hall. 2012. Stereocontrol strategies in the
asymmetric bioreduction of alkenes. Synlett 23:1857-1864.
14.
Rengachari, S., G. A. Bezerra, L. Riegler-Berket, C. C. Gruber, C. Sturm, U. Taschler, A.
1
Boeszoermenyi, I. Dreveny, R. Zimmermann, K. Gruber, and M. Oberer. 2012. The
structure of monoacylglycerol lipase from Bacillus sp. H257 reveals unexpected conservation
of the cap architecture between bacterial and human enzymes. BBA-Mol. Cell Biol. L.
1821:1012-1021.
15.
Łyskowski, A., M. Tengg, G. Steinkellner, H. Schwab, M. Gruber-Khadjawi, and K.
Gruber. 2012. Crystallisation of the novel S-adenosyl-L-methionine dependent Cmethyltransferase CouO from Streptomyces rishiriensis and preliminary diffraction data
analysis. Acta Cryst. F68:698-700.
16.
Okrob, D., J. Metzner, W. Wiechert, K. Gruber, and M. Pohl. 2012. Tailoring a stabilized
variant of hydroxynitrile lyase from Arabidopsis thaliana. ChemBioChem 13:797-803.
17.
Łyskowski, A., K. Steiner, I. Hajnal, G. Steinkellner, H. Schwab, and K. Gruber. 2012.
Crystallization of a novel metal-containing cupin from Acidobacterium sp. and preliminary
diffraction data analysis. Acta Cryst. F68:451-454.
18.
Hissa, D. C., G. A. Bezerra, B. Obrist, R. Birner-Grünberger, V. M. M. Melo, and K.
Gruber. 2012. Crystallization and preliminary X-ray diffraction of the surfactant protein lvranaspumin from the frog Leptodactylus vastus. Acta Cryst. F68:321-323.
19.
Bezerra, G. A., E. Dobrovetsky, A. Seitova, S. Dhe-Paganon, and K. Gruber. 2012.
Crystallization and preliminary X-ray diffraction analysis of human dipeptidyl peptidase 10
(DPPY), a component of voltage-gated potassium channels. Acta Cryst. F68:214-217.
20.
Rangel, T. B. A., B. A. M. Rocha, G. A. Bezerra, A. M. S. Assreuy, A. d. F. Pires, A. S. F.
d. Nascimento, M. J. B. Bezerra, K. S. d. Nascimento, C. S. Nagano, A. H. Sampaio, K.
Gruber, P. Delatorre, P. M. B. Fernandes, and B. S. Cavada. 2012. Crystal structure of a
pro-inflammatory lectin from the seeds of Dioclea wilsonii standl. Biochimie 94:525-532.
21.
Ribitsch, D., S. Heumann, W. Karl, J. Gerlach, R. Birner-Grünberger, K. Gruber, I.
Eiteljörg, P. Remler, P. Siegert, J. Lange, K.-H. Maurer, G. Berg, G. M. Gübitz, and H.
Schwab. 2012. Extracellular serine proteases from Stenotrophomonas maltophilia: screening,
isolation and heterologous expression in E.coli. J. Biotechnol. 157:140-147.
22.
Ribitsch, D., E. H. Acero, K. Greimel, A. Dellacher, S. Zitzenbacher, A. Marold, R. D.
Rodriguez, G. Steinkellner, K. Gruber, H. Schwab, and G. M. Guebitz. 2012. A new
esterase from Thermobifida halotolerans hydrolyses polyethylene terephthalate (PET) and
polylactic acid (PLA). Polymers 4:617-629.
23.
Oberdorfer, G., G. Steinkellner, C. Stueckler, K. Faber, and K. Gruber. 2011.
Stereopreferences of Old Yellow Enzymes: Structure correlations and sequence patterns in
enoate reductases. ChemCatChem 3:1562-1566.
24.
Gruber, K., B. Puffer, and B. Kräutler. 2011. Vitamin B12-derivatives - enzyme cofactors and
ligands of proteins and nucleic acids. Chem. Soc. Rev. 40:4346-4363.
25.
Binter, A., G. Oberdorfer, S. Nerstheimer, S. Hofzumahaus, G. Altenbacher, K. Gruber,
and P. Macheroux. 2011. Characterization of the PLP-dependent aminotransferase NikK
from Streptomyces tendae and its putative role in nikkomycin biosynthesis. FEBS J.
278:4122-4135.
26.
Schrittwieser, J. H., V. Resch, J. H. Sattler, W.-D. Lienhart, K. Durchschein, A. Winkler,
K. Gruber, P. Macheroux, and W. Kroutil. 2011. Biocatalytic enantioselective oxidative C-C
coupling by aerobic C-H activation. Angew. Chem. Int. Ed. 50:1068-1071.
27.
Schittmayer, M., A. Glieder, M. K. Uhl, A. Winkler, S. Zach, J. H. Schrittwieser, W.
Kroutil, P. Macheroux, K. Gruber, S. Kambourakis, D. Rozzell, and M. Winkler. 2011. Old
Yellow Enzyme-catalyzed dehydrogenation of saturated ketones. Adv. Synth. Catal. 353:268274.
28.
Herrero Acero, E., D. Ribitsch, G. Steinkellner, K. Gruber, K. Greimel, I. Eiteljörg, E.
Trotscha, W. Zimmermann, M. Zinn, A. Cavaco-Paulo, G. Freddi, H. Schwab, and G. M.
Gübitz. 2011. Enzymatic surface hydrolysis of PET: Effect of structural diversity on kinetic
properties of cutinases from Thermobifida. Macromolecules 44:4632–4640.
29.
Fedosov, S. N., M. Ruetz, K. Gruber, N. U. Fedosova, and B. Kräutler. 2011. A blue
corrinoid from partial degradation of vitamin B12 in aqueous bicarbonate - Spectra, structure
2
and interaction with proteins of B12-transport. Biochemistry 50:8090-8101.
30.
Lang, S., K. Gruber, S. Mihajlovic, R. Arnold, M.-A. Jehl, T. Rattei, K.-U. Fröhlich, and E.
Zechner. 2010. Molecular recognition determinants for type IV secretionof a broad class of
conjugative relaxases. Mol. Microbiol. 78:1539-1555.
31.
Karabec, M., A. Lyskowski, K. C. Tauber, G. Steinkellner, W. Kroutil, G. Grogan, and K.
Gruber. 2010. Structural insights into substrate specificity and solvent tolerance in alcohol
dehydrogenase ADH-‘A’ from Rhodococcus ruber DSM 44541. Chem. Commun. 46:63146316.
32.
Murtaza, S., M. Ruetz, K. Gruber, and B. Kräutler. 2010. Iso-vitamin B12: a B12 that flips its
tail. Chem. Eur. J. 16:10984-10988.
33.
Ribitsch, D., W. Karl, I. Eiteljörg, K. Gruber, R. Birner-Grünberger, P. Remler, S. Wieland,
P. Siegert, K.-H. Maurer, and H. Schwab. 2010. C-terminal truncation of a metagenomederived detergent protease for effective expression in E. coli. J. Biotechnol. 150:408-416.
34.
Ribitsch, D., S. Winkler, K. Gruber, W. Karl, E. Wehrschütz-Sigl, I. Eiteljörg, P. Schratl, P.
Remler, R. Stehr, C. Bessler, N. Mußmann, K. Sauter, K.-H. Maurer, and H. Schwab.
2010. Engineering of choline oxidase from Arthrobacter nicotianae for potential use as
biological bleach in detergents. Appl. Microbiol. Biotechnol. 87:1743-1752.
35.
Schreiner, U., B. Hecher, S. Obrowsky, K. Waich, N. Klempier, G. Steinkellner, K.
Gruber, J. D. Rozzell, A. Glieder, and M. Winkler. 2010. Directed evolution of Alcaligenes
faecalis nitrilase. Enzyme Microb. Tech. 47:140-146.
36.
Seisser, B., R. Zinkl, K. Gruber, F. Kaufmann, A. Hafner, and W. Kroutil. 2010. Cutting
long syntheses short: Access to non-natural tyrosine derivatives employing an engineered
tyrosine phenol lyase. Adv. Synth. Catal. 352:731-736.
37.
Stueckler, C., N. J. Mueller, C. K. Winkler, S. M. Glueck, K. Gruber, G. Steinkellner, and
K. Faber. 2010. Bioreduction of a-methylcinnamaldehyde derivatives: Chemo-enzymatic
TM
TM
asymmetric synthesis of Lilial and Helional . Dalton Trans. 39:8472-8476.
38.
Fesko, K., M. K. Uhl, J. Steinreiber, K. Gruber, and H. Griengl. 2010. Biocatalytic access
to a,a-dialkyl-a-amino acids by a mechanism-based approach. Angew. Chem. Int. Ed. 49:121124.
39.
Winkler, A., K. Motz, S. Riedl, M. Puhl, P. Macheroux, and K. Gruber. 2009. Structural and
mechanistic studies reveal the functional role of bicovalent flavinylation in berberine bridge
enzyme. J. Biol. Chem. 284:19993-20001.
40.
Winkler, A., M. Puhl, H.-J. Weber, T. M. Kutchan, K. Gruber, and P. Macheroux. 2009.
Berberine bridge enzyme catalyzes the six electron oxidation of (S)-reticuline to
dehydroscoulerine. Phytochem. 70:1092-1097.
41.
Binter, A., N. Staunig, I. Jelesarov, B. A. Palfey, S. Deller, K. Gruber, and P. Macheroux.
2009. A single intersubunit salt-bridge affects oligomerization and catalytic activity in a
bacterial quinone reductase. FEBS J. 276:5263-5274.
42.
Steinkellner, G., R. Rader, G. Thallinger, C. Kratky, and K. Gruber. 2009. VASCo:
computation and visualization of annotated protein surface contacts. BMC Bioinformatics
10:32.
43.
Dreveny, I., A. Andryushkova, A. Glieder, K. Gruber, and C. Kratky. 2009. Substrate
binding in the FAD-dependent hydroxynitrile lyase from almond provides insight into the
mechanism of cyanohydrin formation and explains the absence of dehydrogenation activity.
Biochemistry 48:3370-3377.
44.
Überbacher, B., G. Oberdorfer, K. Gruber, and K. Faber. 2009. Epoxide-hydrolase-initiated
hydrolysis/rearrangement cascade of a methylene-interrupted bis-epoxide yields chiral THFmoieties without involvement of a 'cyclase'. ChemBioChem 10:1697-1704.
45.
Wenzl, M. V., M. Beretta, A. C. F. Gorren, A. Zeller, P. K. Baral, K. Gruber, M. Russwurm,
D. Koesling, K. Schmidt, and B. Mayer. 2009. Role of the general base Glu-268 in
nitroglycerin bioactivation and superoxide formation by aldehyde dehydrogenase-2. J. Biol.
Chem. 284:19878-19886.
3
46.
Avi, M., G. Steinkellner, J. Keilitz, C. Hajji, R. Haag, K. Gruber, and H. Griengl. 2009. αand β-oxygenated aldehydes derived from Diels-Alder reactions as substrates for
hydroxynitrile lyases. J. Mol. Catal. B 61:268-273.
47.
Strohmeier, G. A., T. Sovic, G. Steinkellner, F. S. Hartner, A. Andryushkova, T.
Purkarthofer, A. Glieder, K. Gruber, and H. Griengl. 2009. Investigation of lipase-catalyzed
Michael-type carbon-carbon bond formations. Tetrahedron 65:5663-5668.
48.
Ribitsch, D., W. Karl, E. Wehrschütz-Sigl, S. Tutz, P. Remler, H.-J. Weber, K. Gruber, R.
Stehr, C. Bessler, N. Hoven, K. Sauter, K.-H. Maurer, and H. Schwab. 2009. Heterologous
expression and characterization of choline oxidase from the soil bacterium Arthrobacter
nicotianae. Appl. Microbiol. Biotechnol. 81:875-886.
49.
Guterl, J.-K., J. Andexer, T. Sehl, J. von Langermann, I. Frindi-Wosch, T. Rosenkranz, J.
Fitter, K. Gruber, U. Kragl, T. Eggert, and M. Pohl. 2009. Uneven twins: Comparison of two
hydroxynitrile lyases with α/β-hydrolase fold. J. Biotechnol. 141:166-173.
50.
Winkler, A., A. Lyskowski, S. Riedl, M. Puhl, T. M. Kutchan, P. Macheroux, and K.
Gruber. 2008. A concerted mechanism for berberine bridge enzyme. Nat. Chem. Biol. 4:739741.
51.
Baral, P. K., N. Jajčanin-Jozić, S. Deller, P. Macheroux, M. Abramić, and K. Gruber.
2008. The first structure of dipeptidyl-peptidase III provides insight into the catalytic
mechanism and mode of substrate binding. J. Biol. Chem. 283:22316-22324.
52.
Pscheidt, B., Z. Liu, R. Gaisberger, M. Avi, W. Skranc, K. Gruber, H. Griengl, and A.
Glieder. 2008. Efficient biocatalytic synthesis of (R)-pantolactone. Adv. Synth. Catal.
350:1943-1948.
53.
Murtaza, S., P. Butler, C. Kratky, K. Gruber, and B. Kräutler. 2008. A crystalline B12 dimer
from b-cyano-neocobyrate. Chem. Eur. J. 14:7521-7524.
54.
Schmidt, A., K. Gruber, C. Kratky, and V. Lamzin. 2008. Atomic resolution crystal structures
and quantum chemistry meet to reveal subtleties of hydroxynitrile lyase catalysis. J. Biol.
Chem. 283:21827-21836.
55.
Beretta, M., K. Gruber, A. Kollau, M. Russwurm, D. Koesling, W. Goessler, W. M. Keung,
K. Schmidt, and B. Mayer. 2008. Bioactivation of nitroglycerin by purified mitochondrial and
cytosolic aldehyde dehydrogenases. J. Biol. Chem. 283:17873-17878.
56.
Ruckenstuhl, C., A. Poschenel, R. Possert, P. K. Baral, K. Gruber, and F. Turnowsky.
2008. Structure-function correlations of two highly conserved motifs in yeast squalene
epoxidase. Antimicrob. Agents Chemother. 52:1496-1499.
57.
Liu, Z., B. Pscheidt, M. Avi, R. Gaisberger, F. S. Hartner, C. Schuster, W. Skranc, K.
Gruber, and A. Glieder. 2008. Laboratory evolved biocatalysts for stereoselective syntheses
of substituted benzaldehyde cyanohydrins. ChemBioChem 9:58-61.
58.
Hall, M., C. Stueckler, H. Ehammer, E. Pointner, G. Oberdorfer, K. Gruber, B. Hauer, R.
Stuermer, W. Kroutil, P. Macheroux, and K. Faber. 2008. Asymmetric bioreduction of C=C
bonds using enoate reductases OPR1, OPR3 and YqjM: Enzyme-based stereocontrol. Adv.
Synth. Catal. 350:411-418.
59.
Oberer, M., K. Zangger, K. Gruber, and W. Keller. 2007. The solution structure of ParD, the
antidote of the ParDE toxin-antitoxin module, provides the structural basis for DNA and toxin
binding. Prot. Sci. 16:1676-1688.
60.
Hannibal, L., S. D. Bunge, R. van Eldick, D. W. Jacobsen, C. Kratky, K. Gruber, and N. E.
Brasch. 2007. Synthesis and X-ray structural characterization of imidazolylcobalamin and
histidinylcobalamin: Cobalamin models for aquacobalamin bound to the B12 transporter protein
transcobalamin. Inorg. Chem. 46: 3613-3618.
61.
Fechter, M. H., K. Gruber, M. Avi, W. Skranc, C. Schuster, P. Pöchlauer, K. O. Klepp, and
H. Griengl. 2007. Stereoselective biocatalytic synthesis of (S)-2-hydroxy-2-methylbutyric acid
via substrate engineering using “thio-disguised” precursors and oxynitrilase-catalysis. Chem.
Eur. J. 13: 3369-3376.
4
62.
Gartler, G., C. Kratky, and K. Gruber. 2007. Structural determinants of the enantioselectivity
of the hydroxynitrile lyase from Hevea brasiliensis. J. Biotechnol. 129: 87-97.
63.
Weis, R., R. Gaisberger, K. Gruber, and A. Glieder. 2007. Serine scanning - a tool to prove
the consequences of N-glycosylation of proteins. J. Biotechnol. 129: 50-61.
64.
Ivancic, M., G. Valinger, K. Gruber, and H. Schwab. 2007. Inverting enantioselectivity of
Burkholderia gladioli esterase EstB by directed and designed evolution. J. Biotechnol. 129:
109-122.
65.
Ruckenstuhl, C., S. Lang, A. Poschenel, A. Eidenberger, P. K. Baral, P. Kohut, I. Hapala,
K. Gruber, and F. Turnowsky. 2007. Characterization of squalene epoxidase from
Saccharomyces cerevisiae by applying terbinafine-sensitive varaints. Antimicrob. Agents
Chemother. 51:275-284.
66.
Purkarthofer, T., K. Gruber, M. Gruber-Khadjawi, K. Waich, W. Skranc, D. Mink, and H.
Griengl. 2006. The hydroxynitrile lyase from Hevea brasiliensis also catalyzes nitroaldol
reactions - the first example of a biocatalytic Henry reaction. Angew. Chem. Int. Ed. 45:34543456.
67.
Butler, P., M.-O. Ebert, A. Lyskowski, K. Gruber, C. Kratky, and B. Kräutler. 2006. Vitamin
B12: a methyl group without a job? Angew. Chem. Int Ed. 45: 989-993.
68.
Weis, R., R. Gaisberger, W. Skranc, K. Gruber, and A. Glieder. 2005. Carving the Active
Site of Almond R-HNL for Increased Enantioselectivity. Angew. Chem. Int. Ed. 44:4700-4704.
69.
Purkarthofer, T., K. Gruber, M. H. Fechter, and H. Griengl. 2005. Asymmetric biocatalytic
hydrocyanation of pyrrole carboxaldehydes. Tetrahedron 61:7661-7668.
70.
Morokutti, A., A. Lyskowski, S. Sollner, E. Pointner, T. B. Fitzpatrick, C. Kratky, K.
Gruber, and P. Macheroux. 2005. Structure and Function of YcnD from Bacillus subtilis, a
flavin containing oxidoreductase. Biochemistry 44:13724-13733.
71.
Gschösser, S., K. Gruber, C. Kratky, C. Eichmüller, and B. Kräutler. 2005. B12-retroRiboswitches: Constitutional Switching of B12-Coenzymes Induced by Nucleotides. Angew.
Chem. Int. Ed. 44:2284-2288.
72.
Gschösser, S., R. B. Hannak, R. Konrat, K. Gruber, C. Mikl, C. Kratky, and B. Kräutler.
2005. Homocoenzyme B12 and bishomocoenzyme B12: Covalent structural mimics for
homolyzed, enzyme-bound coenzyme B12. Chem. Eur. J. 11:81-93.
73.
Stranzl, G. R., K. Gruber, G. Steinkellner, K. Zangger, H. Schwab, and C. Kratky. 2004.
Observation of a short, strong hydrogen bond in the active site of hydroxynitrile lyase from
Hevea brasiliensis explains a large pKa-shift of the catalytic base induced by the reaction
intermediate. J. Biol. Chem. 279:3699-3707.
74.
Heilmayer, W., R. Smounig, K. Gruber, W. M. F. Fabian, C. Reidlinger, C. O. Kappe, C.
Wentrup, and G. Kollenz. 2004. 2,6,9-Trioxabicyclo[3.3.1]nona-3,7-dien-4-oyl and
tetraoxaadamantan-9-oyl functionalized aromatic di- and triamines: Synthesis,
stereochemistry and complexation. Tetrahedron 60:2857-2867.
75.
Gruber, K., G. Gartler, B. Krammer, H. Schwab, and C. Kratky. 2004. Reaction mechanism
of hydroxynitrile lyases of the a/b-hydrolase superfamily: The 3D structure of the transient
enzyme-substrate complex certifies the crucial role of Lys236. J. Biol. Chem. 279:2050120510.
76.
Avi, M., M. H. Fechter, K. Gruber, F. Belaj, P. Pöchlauer, and H. Griengl. 2004.
Hydroxynitrile lyase catalysed synthesis of heterocyclic (R)- and (S)-cyanohydrins.
Tetrahedron 60:10411-10418.
77.
Gruber, K., and C. Kratky. 2004. Biopolymers for biocatalysis: Structure and catalytic
mechanism of hydroxynitrile lyases. J. Polymer Sci., Sect. A 42:479-486.
78.
Kräutler, B., W. Fieber, S. Ostermann, M. Fasching, K.-H. Ongania, K. Gruber, C. Kratky,
C. Mikl, A. Siebert, and G. Diekert. 2003. The cofactor of tetrachloroethene reductive
dehalogenase of Dehalospirillum multivorans is norpseudo-B12, a new type of a natural
corrinoid. Helv. Chim. Acta 86:3698-3716.
5
79.
Glieder, A., R. Weis, W. Skranc, P. Pöchlauer, I. Dreveny, S. Majer, M. Wubbolts, H.
Schwab, and K. Gruber. 2003. Comprehensive step-by-step engineering of an (R)hydroxynitrile lyase for large-scale asymmetric synthesis. Angew. Chem. Int. Ed. 42:48154818.
80.
Dreveny, I., C. Kratky, and K. Gruber. 2002. The active site of hydroxynitrile lyase from
Prunus amygdalus: Modeling studies provide new insights into the mechanism of
cyanogenesis. Prot. Sci. 11:292-300.
81.
Gruber, K., and C. Kratky. 2002. Coenzyme B12 dependent glutamate mutase. Curr. Opin.
Chem. Biol. 6:598-603.
82.
Schwenninger, R., J. Schlögl, J. Maynollo, K. Gruber, P. Ochsenbein, H.-B. Bürgi, R.
Konrat, and B. Kräutler. 2001. Metal-complexes of a biconcave porphyrin with D4-structure Versatile chiral shift agents. Chem. Eur. J. 7:2676-2686.
83.
Gruber, K., R. Reitzer, and C. Kratky. 2001. Radical Shuttling in a Protein: Ribose
Pseudorotation Controls Alkyl Radical Transfer in the Coenzyme B12 Dependent Glutamate
Mutase. Angew. Chem. Int. Ed. 40:3377-3380.
84.
Gruber, K. 2001. Elucidation of the Mode of Substrate Binding to Hydroxynitrile Lyase from
Hevea brasiliensis. Proteins 44:26-31.
85.
Dreveny, I., K. Gruber, A. Glieder, A. Thompson, and C. Kratky. 2001. The hydroxynitrile
lyase from almond: A lyase that looks like an oxidoreductase. Structure 9:803-815.
86.
Champloy, F., K. Gruber, G. Jogl, and C. Kratky. 2000. XAS Spectroscopy reveals X-rayinduced photoreduction of free and protein-bound B12 cofactors. J. Synchrotron Rad. 7:267273.
87.
Zuegg, J., K. Gruber, M. Gugganig, U. G. Wagner, and C. Kratky. 1999. 3D structures of
enzyme-substrate complexes of the hydroxynitrile lyase from Hevea brasiliensis. Prot. Sci.
8:1990-2000.
88.
Reitzer, R., K. Gruber, G. Jogl, U. G. Wagner, H. Bothe, W. Buckel, and C. Kratky. 1999.
Glutamate mutase from Clostridium cochlearium: the structure of a coenzyme B12-dependent
enzyme provides new mechanistic insights. Structure 7:891-902.
89.
Gruber, K., M. Gugganig, U. G. Wagner, and C. Kratky. 1999. Atomic resolution crystal
structure of hydroxynitrile lyase from Hevea brasiliensis. Biol. Chem. 380:993-1000.
90.
Gruber, K., B. Zhou, K. N. Houk, R. A. Lerner, C. G. Shevlin, and I. A. Wilson. 1999.
Structural basis for antibody catalysis of a disfavored ring closure reaction. Biochemistry
38:7062-7074.
91.
Gruber, K., G. Klintschar, M. Hayn, A. Schlacher, W. Steiner, and C. Kratky. 1998.
Thermophilic xylanase from Thermomyces lanuginosus: High resolution X-ray structure and
modeling studies. Biochemistry 37:13475-13485.
92.
Turel, I., I. Leban, and K. Gruber. 1996. The crystal structure and characterization of a
copper(II) complex with a guanosine-5'-monophosphate analog (acyclovir monophosphate). J.
Inorg. Biochem. 63:41-48.
93.
Turel, I., I. Leban, M. Zupancic, P. Bukovec, and K. Gruber. 1996. An adduct of
magnesium sulfate with a member of the quinolone family (ciprofloxacin). Acta Cryst.
C52:2443-2445.
94.
Turel, I., K. Gruber, I. Leban, and N. Bukovec. 1996. Synthesis, crystal structure and
characterization of three novel compounds of the quinolone family member (norfloxacin). J.
Inorg. Biochem. 61:197-212.
95.
Leban, I., P. Segedin, and K. Gruber. 1996. Bis(Benzoato-O,O')bis(NicotinamideN)Copper(II). Acta Cryst. C52:1096-1098.
96.
Kräutler, B., T. Müller, J. Maynollo, K. Gruber, C. Kratky, P. Ochsenbein, D.
Schwarzenbach, and H. B. Bürgi. 1996. A topochemically controlled, regiospecific fullerene
bisfunctionalization. Angew. Chem. Int. Ed. 35:1204-1206.
6
97.
Kollegger, G. M., H. Siegl, K. Hassler, and K. Gruber. 1996. Synthesis and molecular
structure of decamethyl-1,4-dibismutha-2,3,5,6,7-pentasilabicyclo[2.2.1]heptane.
Organometallics 15:4337-4338.
98.
Gspaltl, P., S. Graschy, H. Siegl, E. Hengge, and K. Gruber. 1996. Novel bicyclic Si-ring
systems. J. Organomet. Chem. 524:187-193.
99.
Spielberger, A., P. Gspaltl, H. Siegl, E. Hengge, and K. Gruber. 1995. Syntheses,
structures and properties of dihydroxypermethylcyclosilanes and
permethyloxahexasilanorbornanes. J. Organomet. Chem. 499:241-246.
100. Kräutler, B., T. Dérer, P. Liu, W. Mühlecker, M. Puchberger, K. Gruber, and C. Kratky.
1995. Oligomethylene bridged vitamin B12 dimers. Angew. Chem. Int. Ed. 34:84-86.
101. Kratky, C., G. Färber, K. Gruber, K. Wilson, Z. Dauter, H.-F. Nolting, R. Konrat, and B.
Kräutler. 1995. Accurate structural data demystify B12: High resolution solid-state structure of
aquocobalamin perchlorate and structural analysis of the aquocobalamin ion in solution. J.
Am. Chem. Soc. 117:4656-4670.
102. Heilmayer, W., T. S. Dalvi, C. O. Kappe, C. Wentrup, K. Gruber, H. Sterk, and G. Kollenz.
1995. A convenient de novo synthesis of functionalised 2,4,5,8-tetraoxaadamantanes. J.
Chem. Soc., Chem. Comm.:797-798.
103. Ramondenc, Y., R. Schwenninger, T. Phan, K. Gruber, C. Kratky, and B. Kräutler. 1994.
Porphyrins with biconcave frameworks. Angew. Chem. Int. Ed. 33:889-891.
104. Kräutler, B., R. Konrat, E. Stupperich, G. Färber, K. Gruber, and C. Kratky. 1994. Direct
evidence for the conformational deformation of the corrin ring by the nucleotide base in
vitamin B12: Synthesis, solution spectroscopic and crystal structure analysis of Co-b-cyanoimidazolyl-cobamide. Inorg. Chem. 33:4128-4139.
105. Aichberger, W. D., J. Aigner, E. Gössinger, K. Gruber, and G. Menz. 1994. Versuche zur
enantiomerenreinen Synthese des Chatancin. I. Synthese des (1R,2S,6S,7R,8S,3'S)-2-(4'Benzyloxy-3'-methylbutoyl)-7-hydroxy-8-isopropyl-1-methylbicyclo[4.4.0]decan-4-on. Monatsh.
Chem. 125:991-1010.
106. Glatter, O., and K. Gruber. 1993. Indirect transformation in reciprocal space: desmearing of
small angle scattering data from partially ordered systems. J. Appl. Cryst. 26:512-518.
107. Engel, N., X. Gossauer, K. Gruber, and C. Kratky. 1993. X-ray molecular structure of a red
bilin derivative from Chlorella protothecoides. Helv. Chim. Acta 76:2236-2238.
Book chapters
108. Kratky, C., and K. Gruber. 2001. Glutamate mutase, p. 983-994. In A. Messerschmidt, R.
Huber, T. L. Poulos, and K. Wieghardt (ed.), Handbook of Metalloproteins. J. Wiley & Sons,
Ltd., Chichester.
109. Gruber, K., and C. Kratky. 2001. Methylmalonyl-CoA mutase, p. 995-1009. In A.
Messerschmidt, R. Huber, T. L. Poulos, and K. Wieghardt (ed.), Handbook of Metalloproteins.
J. Wiley & Sons, Ltd., Chichester.
110. Gruber, K., and C. Kratky. 2001. Cobalamin-dependent methionine synthase, p. 1010-1022.
In A. Messerschmidt, R. Huber, T. L. Poulos, and K. Wieghardt (ed.), Handbook of
Metalloproteins. J. Wiley & Sons, Ltd., Chichester.
111. Gruber, K., G. Jogl, G. Klintschar, and C. Kratky. 1998. High-resolution structures of
cobalamins, p. 335-347. In B. Kräutler and B. Golding (ed.), Vitamin B12 and B12-proteins.
Wiley-VCH, Weinheim, Chichester, New York, Toronto, Brisbane, Singapore.
Patents
112. Bessler, C., R. Stehr, K.-H. Maurer, H. Schwab, D. Ribitsch, P. Remler, P. Schratl, K.
Gruber, and W. Karl. 2007. Choline oxidases with modified substrate specificity for in situ
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peroxide generation in cosmetics and cleansing compositions. PCT Int. Appl., WO
2007045398.
113. Skranc, W., A. Glieder, K. Gruber, R. Weis, O. Maurer, and R. Gaisberger. 2006. Rhydroxynitrile lyases having improved substrate acceptance and the use thereof. Wo patent
2006076965.
114. Griengl, H., T. Purkarthofer, W. Skranc, K. Gruber, M. Gruber-Khadjawi, D. Mink. 2005.
Production of ß-hydroxy nitro compounds made from aldehydes and nitroalkanes using
hydroxynitrile lyase. PCT Int. Appl., WO 2005073389.
115. Skranc, W., A. Glieder, K. Gruber, R. Weis, and R. Luiten. 2004. Rosaceae R-hydroxynitrile
lyase mutants with improved substrate tolerance and pH stability and their use in preparation
of chiral cyanohydrins. Wo patent 2004083424.
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