Effects of Catecholamine Depletion in Unmedicated, Remitted

Effects of Catecholamine Depletion in Unmedicated, Remitted

Simona Grob (Autor)
Effects of Catecholamine Depletion in Unmedicated, Remitted
Subjects with Bulimia Nervosa and Healthy Subjects
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Contents
Contents
1 Introduction ........................................................................................................... 1
2 Theoretical Background ....................................................................................... 3
2.1 Bulimia Nervosa ........................................................................................... 3
2.1.1 Definition and Diagnosis ............................................................................ 4
2.1.2 Epidemiology and Comorbidities ............................................................... 5
2.1.3 Courses and Prognosis.............................................................................. 6
2.1.4 Etiology and Pathogenesis ........................................................................ 6
2.1.5 Evidence-based Treatments ...................................................................... 9
2.2 Neurobiology of Bulimia Nervosa ............................................................... 13
2.2.1 Monoaminergic Systems.......................................................................... 16
2.2.2 Serotoninergic System ............................................................................. 17
2.2.3 Noradrenergic System ............................................................................. 19
2.2.4 Dopaminergic System .............................................................................. 21
2.2.5 Dopamine and Reward ............................................................................ 23
2.3 Monoamine Depletion ................................................................................ 25
2.3.1 Tryptophan Depletion............................................................................... 25
2.3.2 Catecholamine Depletion ......................................................................... 27
3 Report 1 ............................................................................................................... 31
3.1 Grob, S. et al. (2013) Behavioral Response to Catecholamine Depletion in
Unmedicated, Remitted Subjects with Bulimia Nervosa and Healthy
Subjects. Biological Psychiatry S0006-3223(13)00835-4.
Article in press. Epub ahead of print................................................... 31
4 Report 2 ............................................................................................................... 39
4.1 Grob, S. et al. (2012) Dopamine- Related Deficit in Reward Learning After
Catecholamine Depletion in Unmedicated, Remitted Subjects with
Bulimia Nervosa. Neuropsychopharmacology 37 (8): 1945-52 .......... 39
5 General Discussion ............................................................................................ 48
6 Bibliography ........................................................................................................ 53
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