Prevalence of HCV infection and associated factors - SIGAA
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Prevalence of HCV infection and associated factors - SIGAA
Revista da Sociedade Brasileira de Medicina Tropical http://dx.doi.org/10.1590/0037-‐8682-‐0153-‐2013 Prevalence of HCV infection and associated factors among illicit drug users in Breves, State of Pará, northern Brazil Suzy Danielly Barbosa Pacheco[1], Gláucia Caroline Silva-‐Oliveira[1],[5], Luciana Maria Cunha Maradei-‐Pereira[2], José Ângelo Barletta Crescente[3], José Alexandre Rodrigues de Lemos[2],[4] and Aldemir Branco de Oliveira-‐Filho[2],[5] >@)DFXOGDGHGH&LrQFLDV1DWXUDLV&DPSXVGR0DUDMy%UHYHV8QLYHUVLGDGH)HGHUDOGR3DUi%UHYHV3$>@&HQWURGH+HPDWRORJLDH+HPRWHUDSLDGR3DUi %HOpP3$>@1~FOHRGH0HGLFLQD7URSLFDO8QLYHUVLGDGH)HGHUDOGR3DUi%HOpP3$>@,QVWLWXWRGH&LrQFLDV%LROyJLFDV8QLYHUVLGDGH)HGHUDOGR3DUi Belém, PA. [5]. Instituto de Estudos Costeiros, Universidade Federal do Pará, Bragança, PA. ABSTRACT Introduction:,OOLFLWGUXJXVHUV'8VDUHYXOQHUDEOHWRKHSDWLWLV&YLUXV+&9LQIHFWLRQ7KHVKDUHGXVHRILOOLFLWGUXJVLVWKH PDLQPHWKRGRI+&9WUDQVPLVVLRQMethods: A cross-sectional study was conducted in Breves, in northern Brazil. We surveyed '8V WR GHWHUPLQH WKH SUHYDOHQFH RI DQG IDFWRUV DVVRFLDWHG ZLWK +&9 LQIHFWLRQ Results: 7KH SUHYDOHQFH RI DQWL+&9 DQWLERGLHVZDVDQGWKHSUHYDOHQFHRIKHSDWLWLV&YLUXVULERQXFOHLFDFLG+&951$ZDV+HSDWLWLV&YLUXVLQIHFWLRQ ZDVDVVRFLDWHGZLWKWDWWRRVLQWUDYHQRXVGUXJXVHVKDUHGXVHRIHTXLSPHQWIRUGUXJXVHGUXJXVHIRUORQJHUWKDQ\HDUVDQG daily drug use. Conclusions: 6WUDWHJLHVIRUSUHYHQWLQJDQGFRQWUROOLQJ+&9WUDQVPLVVLRQVKRXOGEHLPSOHPHQWHGDPRQJ'8V Keywords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t is known that most illicit drug users in Pará do not consume LQMHFWHGGUXJVDQGDUHLQIHFWHGZLWK+&9JHQRW\SH10,117KLV VWXG\HVWLPDWHGWKHSUHYDOHQFHRI+&9LQIHFWLRQDQGDVVHVVHG WKHIDFWRUVDVVRFLDWHGZLWK+&9LQIHFWLRQLQLOOLFLWGUXJXVHUV LQWKHPXQLFLSDOLW\RI%UHYHV6WDWHRI3DUiQRUWKHUQ%UD]LO 7KLVFURVVVHFWLRQDOVWXG\RIDQRQSUREDELOLVWLFFRQYHQLHQFH VDPSOH ZDV EDVHG RQ LQIRUPDWLRQ DQG ELRORJLFDO VDPSOHV SURYLGHGE\LOOLFLWGUXJXVHUVLQDQDUHDRILQWHQVHLOOLFLWGUXJ XVHORFDWHGLQ%UHYHV 6 2$UFKLSHODJR RI0DUDMy3DUiQRUWKHUQ%UD]LO,OOLFLWGUXJXVHUVLQDUHDVRI LQWHQVH GUXJ FRQVXPSWLRQ ZHUH VDPSOHG XVLQJ WKH VQRZEDOO WHFKQLTXH11 ,QGLYLGXDOV ZHUH HOLJLEOH IRU WKH VWXG\ LI WKH\ ZHUHROGHUWKDQ\HDUVRIDJHDQGDJUHHGWRDQVZHUDVSHFL¿F Address to: Dr. Aldemir Branco Oliveira-Filho. Faculdade de Ciências Naturais, Instituto de Estudos Costeiros, Universidade Federal do Pará. Al. Leandro Ribeiro, s/n. Aldeia, 68600-000 Bragança, Pará, Brasil. Phone: 55 91 3425-1593;; Fax: 55 91 3425-1209. e-mail: ROLY¿OKR#XISDEU Received 21 July 2013 Accepted 27 November 2013 TXHVWLRQQDLUH DQG KDYH D EORRG VDPSOH WDNHQ DQG WHVWHG IRU PROHFXODUDQGVHURORJLFPDUNHUVLQWKHSHULRGIURP$XJXVWWR 'HFHPEHU7KH5HVHDUFKDQG (WKLFV&RPPLWWHHRI WKH Núcleo de Medicina TropicalRIWKHUniversidade Federal do ParáDSSURYHGWKHVWXG\SURWRFRO&(3107 $OOVDPSOHVZHUHWHVWHGIRU+&9DQWLERGLHVDQGKHSDWLWLV& YLUXVULERQXFOHLFDFLG+&951$$QWL+&9DQWLERGLHVZHUH WHVWHG E\ HQ]\PH LPPXQRDVVD\ (,$ 0XUH[ DQWL+&9 0XUH[%LRWHFK+&951$ZDVGHWHFWHGE\UHDOWLPHSRO\PHUDVH FKDLQUHDFWLRQ3&5XVLQJEDVHSDLUVRIWKH¶XQWUDQVODWHG UHJLRQ 875 DV GHVFULEHG HOVHZKHUH9 &RQ¿GHQFH LQWHUYDOV &,VZHUHGHWHUPLQHGIRULQIHFWLRQSUHYDOHQFHHVWLPDWHV6LPSOH DQGPXOWLSOHORJLVWLFUHJUHVVLRQVZHUHFDOFXODWHGWRDVVHVVWKH LQGHSHQGHQWHIIHFWVRIYDULDEOHV127KH¿WRIWKH¿QDOPRGHOZDV DVVHVVHGXVLQJWKH+RVPHU/HPHVKRZJRRGQHVVRI¿WWHVW7ZR GH¿QLWLRQVRI+&9LQIHFWLRQZHUHXVHG,DQWL+&9SRVLWLYLW\ VKRZQE\(,$DQG,,+&951$GHWHFWLRQE\UHDOWLPH3&5$OO VWDWLVWLFDODQDO\VHVZHUHSHUIRUPHGXVLQJ,%063666WDWLVWLFV ,QWRWDOLOOLFLWGUXJXVHUVSDUWLFLSDWHGLQWKLVVWXG\7KH PDMRULW\ RI SDUWLFLSDQWV ZHUH PDOH 7KH PHDQ DJH was 28.5 years (range, 18-51 years;; standard deviation [SD] ± \HDUV7KHPDMRULW\RISDUWLFLSDQWVKDG!\HDUVRIHGXFDWLRQ DQGEHORQJHGWRIDPLOLHVZLWKPRQWKO\LQFRPHVRIXS to R$1,090.00 (US$545.00). 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REFERENCES 1. $FHLMDV&5KRGHV7*OREDOHVWLPDWHVRISUHYDOHQFHRI+&9LQIHFWLRQ DPRQJLQMHFWLQJGUXJXVHUV,QW-'UXJ3ROLF\ 2. 0DUWLQV71DUFLVR6FKLDYRQ-/6FKLDYRQ//(SLGHPLRORJ\RIKHSDWLWLV &YLUXVLQIHFWLRQ5HY$VVRF0HG%UDV 3. 2OLYHLUD0/+DFNHU0$2OLYHLUD6$7HOOHV352.0<RVKLGD&) HWDO7KH¿UVWVKRWWKHFRQWH[WRI¿UVWLQMHFWLRQRILOOLFLWGUXJVRQJRLQJ LQMHFWLQJ SUDFWLFHV DQG KHSDWLWLV & LQIHFWLRQ LQ 5LR GH -DQHLUR %UD]LO Cad Saude Publica 2006;; 22:861-870. 4. /RSHV &/5 7HOHV 6$ (VStULWR6DQWR 03 /DPSH ( 5RGULJXHV )3 0RWWD&DVWUR $5& HW DO 3UHYDOHQFH ULVN IDFWRUV DQG JHQRW\SHV RI KHSDWLWLV & YLUXV LQIHFWLRQ DPRQJ GUXJ XVHUV &HQWUDO:HVWHUQ %UD]LO Rev Saude Publica 2009;; 43:S1-S7. 5. 1RYDLV $&0 /RSHV &/5 5HLV 156 6LOYD $0& 0DUWLQV 50% 6RXWR)-'3UHYDOHQFHRIKHSDWLWLV&YLUXVLQIHFWLRQDQGDVVRFLDWHGIDFWRUV DPRQJPDOHLOOLFLWGUXJXVHUVLQ&XLDEi0DWR*URVVR%UD]LO0HP,QVW Oswaldo Cruz 2009;; 104:892-896. 6. 2OLYHLUD 0/ %DVWRV ), 7HOOHV 35 +DFNHU 0$ 2OLYHLUD 6$1 0LJXHO -& HW DO (SLGHPLRORJLFDO DQG JHQHWLF DQDO\VHV RI +HSDWLWLV & YLUXV WUDQVPLVVLRQ DPRQJ \RXQJVKRUW DQG ORQJWHUP LQMHFWLQJ GUXJ XVHUVIURP5LRGH-DQHLUR%UD]LO-&OLQ9LURO 7. 6LOYD0%$QGUDGH706LOYD/.5RGDUW,)/RSHV*%&DUPR70$ HWDO3UHYDOHQFHDQGJHQRW\SHVRIKHSDWLWLV&YLUXVDPRQJLQMHFWLQJGUXJ XVHUV IURP 6DOYDGRU%$ %UD]LO 0HP ,QVW 2VZDOGR &UX] 299-303. 8. 7RUUHV./0DOKHLUR$7DWHQR$/LPD7$0DLD/393LPHQWHO-3' HWDO+HSDWLWLV&YtUXVLQEORRGGRQRUV%UD]LO(PHUJ,QIHFW'LV 15:676-678. 9. 2OLYHLUD)LOKR$%3LPHQWD$6&5RMDV0)0&KDJDV0&0&UHVSR'0 &UHVFHQWH-$%HWDO3UHYDOHQFHDQGJHQRW\SLQJRIKHSDWLWLVFYLUXVLQ EORRG GRQRUV LQ WKH VWDWH RI 3DUi 1RUWKHUQ %UD]LO 0HP ,QVW 2VZDOGR Cruz 2010;; 105:103-106. 10. 6DZDGD/3LQKHLUR$&&/RFNV'3LPHQWD$6&5H]HQGH35&UHVSR'0 HWDO'LVWULEXWLRQRIKHSDWLWLV&YLUXVJHQRW\SHVDPRQJGLIIHUHQWH[SRVXUH FDWHJRULHV LQ WKH 6WDWH RI 3DUi %UD]LOLDQ$PD]RQ 5HY 6RF %UDV 0HG 7URS Pacheco SDB et al -‐ HCV infection among illicit drug users in Breves 11. 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