Graphical Abstracts Essential Structural Features of Novel

Graphical Abstracts Essential Structural Features of Novel

Graphical Abstracts
Medicinal Chemistry, 2014, Vol. 10, No. 6
Graphical Abstracts
Medicinal Chemistry; Vol. 10; 2014, 541
Essential Structural Features of Novel Antischizophrenic Drugs: A Review
Alireza Nematollahi*, Noushin Aminimoghadamfarouj and William Bret Church
* Faculty of Pharmacy A15, The University of Sydney, Sydney NSW 2006, Australia
This article reviews the antischizophrenic agents with focusing on medicinal chemistry aspects. Moreover, the idea of kynurenine
aminotransferase as a potential target is also presented in this review.
Medicinal Chemistry; Vol. 10; 2014, 550
Potential Therapeutic Agents from the Red Sea Organisms
Mohammad Abrar Alam*
* Department of Chemistry and Biochemistry, Rowan University Glassboro NJ 08028, USA
i
Medicinal Chemistry, 2014, Vol. 10, No. 6
Graphical Abstracts
Medicinal Chemistry; Vol. 10; 2014, 564
Effect of 9-hydroxy-- and 7-hydroxy--pyran Naphthoquinones on Trypanosoma Cruzi and
Structure-activity Relationship Studies
David R. da Rocha, Alessandra M.T. de Souza, Ana Carolina G. de Souza, Helena C. Castro, Carlos R. Rodrigues, Rubem
F.S. Menna-Barreto, Solange L. de Castro and Vitor F. Ferreira*
* Departamento de Química Inorgânica, Instituto de Química, UFF, 24020-150, Niterói, RJ, Brazil
Medicinal Chemistry; Vol. 10; 2014, 571
Antiproliferative Evaluation of N-sulfonyl-2-alkyl-six Membered Azacycles. A QSAR Study
Rubén M. Carballo, Leticia G. León, Ramiro F. Quijano-Quiñones, Gonzalo J. Mena-Rejón, Víctor S. Martín, José M.
Padrón* and Juan I. Padrón*
*Instituto Universitario de Bio-Orgánica “Antonio González” (IUBO-AG), Centro de Investigaciones Biomédicas de Canarias (CIBICAN), Universidad
de La Laguna, C/ Astrofísico Francisco Sánchez 2, 38206 La Laguna, Spain;Instituto de Productos Naturales y Agrobiología, CSIC, C/Astrofísico
Francisco Sánchez 3, 38206 La Laguna, Spain
4.8
Predicted pGI50
ii
4.4
4.0
Training set
Test set
4.0
4.4
4.8
Experimental pGI50
Medicinal Chemistry; Vol. 10; 2014, 580
Synthesis, Activity, and QSAR Studies of Tryptamine Derivatives on Third-instar Larvae of
Aedes Aegypti Linn
Rafael R.B. Oliveira, Thaysnara B. Brito, Angelita Nepel, Emmanoel V. Costa, Andersson Barison, Rogéria S. Nunes,
Roseli L.C. Santos and Sócrates C.H. Cavalcanti*
* Medicinal Chemistry Laboratory, Pharmacy Department, Federal University of Sergipe, São Cristóvão, SE, 49100-000, Brazil
Triptamine is known to affect insect behavior, development, and physiology. In view of such facts, we synthesized triptamine
derivatives as potential larvicides against Aedes aegypti, establishing a Structure-Activity Relationship.
O
NH2
NH
R
O
R1
C
R2
N
H
Tryptamine (1)
C6H5N
CH2Cl2
N
H
Graphical Abstracts
Medicinal Chemistry, 2014, Vol. 10, No. 6
Medicinal Chemistry; Vol. 10; 2014, 588
Discovery of Novel Lead in the Group of N-substituted Piperazine Ether Derivatives with
Potential Histamine H3 Receptor Activity
Kamil J. Kuder, Marta Stachnik, Walter Schunack, Ewa Szymaska and Katarzyna Kie-Kononowicz*
* Department of Technology and Biotechnology of Drugs, Jagiellonian University, Medical College, Kraków, 30-688, Poland
Medicinal Chemistry; Vol. 10; 2014, 600
Synthesis, In Vitro Biological Screening and Molecular Docking Studies of Novel CamphorBased Thiazoles
Krzysztof Z. czkowski*, Konrad Misiura, Anna Biernasiuk, Anna Malm, Agata Siwek, Tomasz Plech, Emilia CiokPater, Krzysztof Skowron and Eugenia Gospodarek
* Department of Chemical Technology and Pharmaceuticals, Faculty of Pharmacy, Collegium Medicum, Nicolaus Copernicus University, Jurasza 2, 85089 Bydgoszcz, Poland
This paper demonstrates the synthesis and the antimicrobial and molecular docking study of twelve camphor-based thiazoles.
Among the derivatives, 3i and 5 were found to exhibit antimicrobial activities against Candida spp., MIC 0.12-0.98 g/ml and
Gram-positive bacteria including both pathogenic S. aureus and opportunistic S. epidermidis, MIC 0.98-7.81 g/ml, B. subtilis
and B. cereus, MIC 3.91-31.25 g/ml, and M. luteus, MIC 0.98 g/ml species, respectively.
Medicinal Chemistry; Vol. 10; 2014, 609
Synthesis of Novel 2,3,4-trisubstituted-oxazolidine Derivatives and In Vitro Cytotoxic Evaluation
Saulo F. Andrade, Edmar F.S. Campos, Claudia S. Teixeira, Cristiano C. Bandeira, Stefânia N. Lavorato, Nelilma C.
Romeiro, Caryne M. Bertollo, Mônica C. Oliveira, Elaine M. Souza-Fagundes and Ricardo J. Alves*
* Departamento de Produtos Farmacêuticos, Faculdade de Farmácia, Universidade Federal de Minas Gerais (UFMG), Av. Antônio Carlos, 6627, Belo
Horizonte, MG 31.270-901, Brazil
iii
iv
Medicinal Chemistry, 2014, Vol. 10, No. 6
Graphical Abstracts
Medicinal Chemistry; Vol. 10; 2014, 619
Design, Synthesis and Cytotoxic Activity Evaluation of New Aminosubstituted Benzofurans
Konstantinos Daniilides, Nikolaos Lougiakis, Nicole Pouli, Panagiotis Marakos*, Pinelopi Samara and Ourania
Tsitsilonis
*University of Athens, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Panepistimiopolis-Zografou, Athens 15771, Greece
The preparation of new aminosubstituted benzofurans is described. Certain analogues showed noticeable tumor cell growth
inhibition when tested against five human tumor cell lines (MCF-7, SKBR3, SKOV3, HCT-116 and HeLa).
R2
R1
O
OCH3
R1: CO2Et, CH2OH, CH2OCOCH3
R2: N(CH3)2, N
,N
Medicinal Chemistry; Vol. 10; 2014, 628
Discovery of Novel CK2 Leads by Cross-Docking Based Virtual Screening
Haopeng Sun, Xiaowen Wu, Xiaoli Xu, Zhengyu Jiang, Zongliang Liu* and Qidong You*
* China Pharmaceutical University, 24 Tong Jia Xiang Road, Nanjing, China