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178
Paradtim of dogs by Rangeria vit*Iliin
muthem Brazir: clinicar, pathologicar and
**""ffiffitffir1*;$llo
Ap Lorerri,.. ss
orir.iru,, cA pescador,,
NN Silvar, DB Roza', D Driemier,, eCpArarijo.,
LR Meialet'
Vct
parh,
Parh,
Dept Ver Clin
'Sector
Fac re, u"a-Ju ii"i'" iI" G4
Srl fUrnGS), porro Alese, RS, Bmzil
zver Fac,
uFpet. petotas, xs, B-razil ;ncv-u'lici
^"
5PhD
sldenq ISD/IMT, USn Sa" prUo, jfiiraif--e_'mail
[email protected]
ii? rrr*rf ppccil.ffiii,
INTRODUCTION: Rangetiosis m -nanbi_uni*
ls a p,rotszoal disease caused by an
intracellular
parasite of
_dogs called Rangltia oirati. fhis
condlhon affecb especiaily trunrine
doss from
y"as u southern Brazil. Cksrers if cases
Irat
mve Deetr obaerved fram Novenber to March
siace dcks.are
,Auna*r curiuf,fir"lii
seasons. This entity oco.us particularlv'in
vou"l
oogs and Echfiacreriz€dbyanania
ictirusievei
,*rt
generalized lymph'node
:ljetromegaly:
eilaryetrHt
and pcrsisteil bleeding tliroush rhe
nos€, oral caviry and ear nmEins. fire
life"<ycle
of R-. vilalli consists ol an ervthrocvric
developmnhl
g'c*ftC n
srage
*a *.ro".yrr,7*yti""]lri
rhe cyrrylasm
of endothelial ceils.
now€rer, IL viraili_Wrasitized erytlrocytes
are
regilw
as tmcotrmdoo, to rare findings
esoeciallv
m rne cnrontc
ftrm of
clatmt9lL vitdti
drc disease.
$me;urbo;
ultcmal orgarts, marked splenornesrly,
eolarged
tyrnph nodes, lary€
oi
corffi#'blffi
ln rne gastriniestinal
"roo*ir,
tfact and viyid red. nasrv
:.?l:,-p"rrj* suggesring tr"maropo';eiit
sumuaum. Examinatisr of bore nrarrowsrncan
nurrerous R vitolli orgarisms-i;;;
cytoplasrn of endotheliat oells.
were roundish and had a ,oe"Uy
utaiiea llui
git.tl^p and a pinpoint, exc€nrric nucleus.
msrcrogcatly, runy inracytoplasmic protozoa
yere fgund in rhe daot"l;ir .iiGof
from different tissues, parastre$ lpere
most
nttnnrous in rbe hisrotogicat *ato*
oll"rriii
r"yold
ffii p*'**l
;fi;;;
nodes. Eryrhrophagocydri, *o-ie*
nuUnuOeah giant eth were also
ob,served in
t11*_?9"1 urrrastnrcturali,r=_
;i;T;
*
frlo one stngle-, excentric,
electon&sei
ilr.sij
aoubf i
rayerc{. nound to oval structure
conesponrring to
the mcleus, electron&rse gran
Uo mr ocor in svtrm,crG.
rne cftu_cal, pathological and ulf.cfructurel
aryccc or tIrc pa!?sitim of dogs by R
vitalti
les'fillid"#
and.oval, doubljhyered rr*i;;
:Ir"pt^T
uerprued as miioctm&ia
MATERIAL AND MET.8ODS: Historv_
15 rnrn The single p*rirr|f,"ri
hafoufug the parines consisted of ila
souosn Brazit
arc AascriU* i-n tfril
i
iod;. "'
clntrq{ nndlngs, nnnagerrm ad oueorre
ofi
*r.fir rangeliosis were rctneved froi
:lgl.
verennarians; 3ml ofwhole blood uas
coilecld
a crrtrigt cary and inoculalcd W 4
bflrs
L9T samplinganer
Blood smears from both
InOi,lOrat organiirF
],.a3tol€
T-,agl*,r"yer rmsuring 3(hrn. Tbcre r+cre
rising fiorn tE inemat
-lllEl:TlqC
surrac.e
ol me"dcrovilli
parasitophorous vacuole and
:Iending into iB fturrn, ineasuring4G5-d;;;
dtameierad0s
rnm in lengrL wirh"el'ffi;;
cores. Tlrc disease",ar
surgcafly.rernoved and sanryled together
with
-at
hsntcs ad fre CNS fro,nr necrbsies
f;a,gt
clectroo micrus@py. Snpars were
rranufacnurd
rmm ussuesamples and stained withGicmsa
anJ
Panoptic. Ao imrnunohisroctremicaf
ie""rri"l,i
wasperfonned
cattuwrt
ftr lz i*ananh cnaias
^nd-Tomplasnm gorrdii
L-N;:ffi;
stme n iilati
ffiffi,ffi"Hffiffitrtr!*.fi
s'as_,c,ond_ucted
in
conformance
"it[ ni
grtr{emes for-experirEtrat proceOrnc
asser forri
n_F taw I I 9 I i of 05.2 I .03,
"Code for Anirnal:r_r.
Welt-Beingh RS..
RESiULTS;
Tk
cliaical picture in 2 does wirh
riy'r#;ril;
*ith bl";
dog. The il;f;;
r,fc.srn
, rn an.cxperirnental dog
inoculatei
ymgla rrogaransitiied
srgns were observed 5 days
afier rhe
1{, j1{uaeA.rever, mudoU pafl or
inoclrd;
and-btmJ
oozulg rom tle nce. fhe ex1rerienral
aninal
sqgfaDaTr$ty I C days affi:r dE
onser]ffi
1fl
$ffiffi
rm
*:ir,f.iffi '#.il'ffitr47
or
disease. No blood
Frasircs m rickensiil
agenr were found ln ure ren OlooA
spontaneous
or
l g"hemis
ceu;;i;hr;
experimental aasrr.
rry to, t. c i o s o'ii - fi'.
lT_T.t1.? lli
cannum
and T garrdri was mrist€aUy
i"g;i"".
DISCUSSION: The preseot studv shnw
conyncurg evid€nce that rangeliosis
i,
rhesis riarprevious
""repurrte
rlpcn[
qlgelosrs was cluracterized Ay nu*ed mlfor
TuV.*{rypport fte
of canine
o$cotoration of rmrcoEae (iaundioe),
vlscemt tershmaniosis in southem
Brrzil stroul-i
bercviewed.
T-Try$ rcrnbram (ananria) or ye[6wish
addr. fe;;
ii:"J,:['jllffi
medtated
hennlnic
anemii- One ,pooru"eou,
'1,3',X'*1'::ili'*:,*m;
919 ryaed qhaft er reffnrr wiri, irniaoorO
gq.oeqnag and blood transfrrsion. Necronsv
rmourys mctuded diffise pallorof
thecarcass
init
babesiosis,.fld*
od;i;*d-;;;;
nsFtRENCr^s
gyi
tUaliel,f: 1914, Sobre a nrotdstia
tu
ltZii{i'*
+,
caes, chamada
Nambi_uvrf e o seu parasih
(Raascliaviallil. An paul UeC
Ci
r
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